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代表性论文

  1. Jin H, Shi Y, Lv Y, Yuan S, Ramirez CFA, Lieftink C, Wang L, Wang S, Wang C, Dias MH, Jochems F, Yang Y, Bosma A, Hijmans EM, de Groot MHP, Vegna S, Cui D, Zhou Y, Ling J, Wang H, Guo Y, Zheng X, Isima N, Wu H, Sun C, Beijersbergen RL, Akkari L, Zhou W, Zhai B, Qin W, Bernards R. EGFR activation limits the response of liver cancer to lenvatinib. Nature. 2021 Jul;595(7869):730-734. doi: 10.1038/s41586-021-03741-7. Epub 2021 Jul 21. PMID: 34290403.
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  3. Shi J, Wang X, Tang Y, Meng S, Zhang Z, Lu P, Xu J, Yu F, Wang X, Wang Z, Sun Y, Xue J. LY6D identifies persistent stem-like cells driving pancreatic tumourigenesis. Gut. 2026 Jan 16:gutjnl-2025-336460. doi: 10.1136/gutjnl-2025-336460. Epub ahead of print. PMID: 41545197.
  4. Zheng J, Wang S, Xia L, Sun Z, Chan KM, Bernards R, Qin W, Chen J, Xia Q, Jin H. Hepatocellular carcinoma: signaling pathways and therapeutic advances. Signal Transduct Target Ther. 2025 Feb 7;10(1):35. doi: 10.1038/s41392-024-02075-w. PMID: 39915447; PMCID: PMC11802921.
  5. Gao J, Zhang W, Li Q, Zhao D, Cai J, Wang Q, Li X, Liu T, Li J, Xiao W, Li H, Du M, Zhang B, Li P, Tu H, Gan Y. Restricting lipid accumulation in tumor- infiltrating neutrophils mediates caloric restriction-induced anti-cancer effects. Cell Metab. 2025 Dec 5.38(3):598-615.E7. doi: 10.1016/j.cmet.2025.11.007. Epub ahead of print. PMID: 41352341.
  6. Wang J, Xu P, Ji Z, Cheng C, Liu Y, Du G, Zhang S, Miao J, Wang D, Chen R, Li D, Zhang K, Zhao H, Sun Y, Chen X, Jing N, Liu K, He Y, Xi X, Zhang Y, Wang N, Xu L, Yao J, Gao X, Zhou J, Fan S, Wang X, Dong S, Chen F, Hou J, Zhang M, Gao WQ, Shen L, Zhang P, Zhu HH. A Gremlin 1-expressing splenic niche cell population restrains chronic myeloid leukemia by antagonizing the BMP pathway. Nat Cancer. 2025 Apr;6(4):666-681. doi: 10.1038/s43018-025-00933-2. Epub 2025 Mar 17. PMID: 40097655.
  7. Yang W, Wang S, Ji S, Wang J, Lian S, Li Z, Jansen RA, Wu W, Niu K, Sun Z, Jia Q, Zheng J, Zhu H, Deng X, Wang L, Fan Z, Shi Y, Lieftink C, Guan M, Beijersbergen RL, Qin W, Gao Q, Bernards R, Jin H. CRISPR screens identify the ATPase VCP as a druggable therapeutic vulnerability in cholangiocarcinoma. Proc Natl Acad Sci U S A. 2025 Sep 30;122(39):e2519568122. doi: 10.1073/pnas.2519568122. Epub 2025 Sep 24. PMID: 40991439; PMCID: PMC12501119.
  8. Wang J, Liao L, Miao B, Yang B, Li B, Ma X, Fitz A, Wu S, He J, Zhang Q, Ji S, Jin G, Zhang J, Cao Y, Wang H, Qin W, Sun C, Bernards R, Wang C. Deciphering the role of the MALT1-RC3H1 axis in regulating GPX4 protein stability. Proc Natl Acad Sci U S A. 2025 Jan 7;122(1):e2419625121. doi: 10.1073/pnas.2419625121. Epub 2024 Dec 31. PMID: 39739814; PMCID: PMC11725786.
  9. Niu N, Shen X, Wang Z, Chen Y, Weng Y, Yu F, Tang Y, Lu P, Liu M, Wang L, Sun Y, Yang M, Shen B, Jin J, Lu Z, Jiang K, Shi Y, Xue J. Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer. Cancer Cell. 2024 May 13;42(5):869-884.e9. doi: 10.1016/j.ccell.2024.03.005. Epub 2024 Apr 4. PMID: 38579725.
  10. Yang C, Geng H, Yang X, Ji S, Liu Z, Feng H, Li Q, Zhang T, Zhang S, Ma X, Zhu C, Xu N, Xia Y, Li Y, Wang H, Yu C, Du S, Miao B, Xu L, Wang H, Cao Y, Li B, Zhu L, Tang X, Zhang H, Zhu C, Huang Z, Leng C, Hu H, Chen X, Yuan S, Jin G, Bernards R, Sun C, Zheng Q, Qin W, Gao Q, Wang C. Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy. Cancer Cell. 2024 Dec 9;42(12):2064-2081.e19. doi: 10.1016/j.ccell.2024.10.008. Epub 2024 Nov 7. PMID: 39515328.
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  12. Wang H, Yuan S, Zheng Q, Zhang S, Zhang Q, Ji S, Wang W, Cao Y, Guo Y, Yang X, Geng H, Yang F, Xi S, Jin G, Zhang J, Gao Q, Bernards R, Qin W, Wang C. Dual Inhibition of CDK4/6 and XPO1 Induces Senescence With Acquired Vulnerability to CRBN-Based PROTAC Drugs. Gastroenterology. 2024 Jun;166(6):1130-1144.e8. doi: 10.1053/j.gastro.2024.01.025. Epub 2024 Jan 21. PMID: 38262581.
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  14. Zhang L, Jiao K, Liu Y, Xu G, Yang Z, Xiang L, Chen Z, Xu C, Zuo Y, Wu Z, Zheng N, Zhang X, Xia Q, Liu Y. UBXN9 inhibits the RNA exosome function to promote T cell control of liver tumorigenesis. Hepatology. 2024 Nov 1;80(5):1041-1057. doi: 10.1097/HEP.0000000000000711. Epub 2023 Dec 5. PMID: 38051955.
  15. Wang X, Fu SQ, Yuan X, Yu F, Ji Q, Tang HW, Li RK, Huang S, Huang PQ, Qin WT, Zuo H, Du C, Yao LL, Li H, Li J, Li DX, Yang Y, Xiao SY, Tulamaiti A, Wang XF, Dai CH, Zhang X, Jiang SH, Hu LP, Zhang XL, Zhang ZG. A GAPDH serotonylation system couples CD8+ T cell glycolytic metabolism to antitumor immunity. Mol Cell. 2024 Feb 15;84(4):760-775.e7. doi: 10.1016/j.molcel.2023.12.015. Epub 2024 Jan 11. PMID: 38215751.
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  18. Liu T, Li J, Li Q, Liang Y, Gao J, Meng Z, Li P, Yao M, Gu J, Tu H, Gan Y. Environmental eustress promotes liver regeneration through the sympathetic regulation of type 1 innate lymphoid cells to increase IL-22 in mice. Hepatology. 2023 Jul 1;78(1):136-149. doi: 10.1097/HEP.0000000000000239. Epub 2023 Jan 13. PMID: 36631003.
  19. Cheng C, Wang J, Xu P, Zhang K, Xin Z, Zhao H, Ji Z, Zhang M, Wang D, He Y, Jing N, Fan L, Liu K, Li F, Liu C, Gong Y, Cui S, Sun Z, Sun D, Yao X, Li H, Zhang J, Zhang P, Dong B, Xue W, Qian X, Gao WQ, Zhu HH. Gremlin1 is a therapeutically targetable FGFR1 ligand that regulates lineage plasticity and castration resistance in prostate cancer. Nat Cancer. 2022 May;3(5):565-580. doi: 10.1038/s43018-022-00380-3. Epub 2022 May 27. PMID: 35624341.
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  21. Zhou Q, Tian W, Jiang Z, Huang T, Ge C, Liu T, Zhao F, Chen T, Cui Y, Li H, Yao M, Li J, Tian H. A Positive Feedback Loop of AKR1C3-Mediated Activation of NF-κB and STAT3 Facilitates Proliferation and Metastasis in Hepatocellular Carcinoma. Cancer Res. 2021 Mar 1;81(5):1361-1374. doi: 10.1158/0008-5472.CAN-20-2480. Epub 2020 Dec 23. PMID: 33361392.
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  23. Zhang L, Huo Q, Ge C, Zhao F, Zhou Q, Chen X, Tian H, Chen T, Xie H, Cui Y, Yao M, Li H, Li J. ZNF143-Mediated H3K9 Trimethylation Upregulates CDC6 by Activating MDIG in Hepatocellular Carcinoma. Cancer Res. 2020 Jun 15;80(12):2599-2611. doi: 10.1158/0008-5472.CAN-19-3226. Epub 2020 Apr 20. PMID: 32312832.
  24. Hu J, Dong Y, Ding L, Dong Y, Wu Z, Wang W, Shen M, Duan Y. Local delivery of arsenic trioxide nanoparticles for hepatocellular carcinoma treatment. Signal Transduct Target Ther. 2019 Sep 6;4:28. doi: 10.1038/s41392-019-0062-9. PMID: 31637008; PMCID: PMC6799825.
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